Peter Rost, M.D., is a former Pfizer Marketing Vice President providing services as a medical device and drug expert witness and pharmaceutical marketing expert. Judge Sanders: "The court agrees with defendants' view that Dr. Rost is a very adept and seasoned expert witness." He is also the author of Emergency Surgery, The Whistleblower and Killer Drug. You can reach him on rostpeter (insert symbol) hotmail.com. Follow on https://twitter.com/peterrost
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Thursday, July 05, 2007
Did you get screwed?
If you got screwed when you tried to speak up against unethical conduct, contact rostpeter@hotmail.com
The massive effort over the last 50 years by big Pharma and others to cover up and detract from the science showing the paternal age effect on many, many genetic disorders such as Alzheimer's, autism, schizophrenia, diabetes, MS, Crohn's, fibromyalgia, Duchennes's, hemophilia, mental retardation, prostate cancer, etc. etc. has been so successful that most people will argue that there is no male biological clock that affects offspring's risk genetic disorders from their deepest conditioning. The facts show that the very opposite is true and that sperm stem cell DNA is very prone to mutation with age and toxic exposures.
And why would that be in Big Pharma's best interest?
And how would you "cover up" something for 50 years?
These kinds of sweeping accusations help Big Pharma, because they can point to the people using these comments and claim anyone critical is a lunatic.
Gimme a break.
Sure, there are lots of things we don't know, I'm sure that includes impact of paternal age, but to say there is a big conspiracy because what you think is true has not been widely validated or accepted simply helps nail you to the cross.
Some of the studies on paternal age and genetic disorders are cited below. Why is this science unknown to the general public and to doctors who have been taught there is no male biological clock?
http://list.web.net/archives/mnchp-l/2004-April/000508.html "New point mutations in humans are introduced through the male line," says Dolores Malaspina, MD, professor of clinical psychiatry at Columbia University and the New York State Psychiatric Institute. Furthermore, she adds, the number of mutations in sperm increases as men age.
"This has been known since the 50s," said Malaspina. "What is intriguing is why society chooses to ignore this." Society is starting to pay attention. With many couples now deferring childbearing until they are older, the issue of paternal age and increased risk for birth defects is gaining a higher profile. It is also possible, say some experts, that if current trends of older fatherhood continue, it could someday become a public health problem as well as a personal one."
Mol Psychiatry. 2007 May;12(5):419-421.Paternal age and autism are associated in a family-based sample.Cantor RM, Yoon JL, Furr J, Lajonchere CM. [1] 1Department of Human Genetics, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA, USA [2] 2Department of Pediatrics, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA, USA [3] 3AGRE Consortium, Los Angeles, CA, USA.
PMID: 17453057 [PubMed - as supplied by publisher]
The paternal age distribution of the AGRE fathers, whose first child is autistic differs significantly from that of the 'control' sample (P=0.005). A 2 goodness-of-fit test with 2 degrees of freedom was conducted using percents in the 'control' group age categories to calculate the expected values in the AGRE sample. The shift toward higher paternal ages in those with an affected first-born is seen most dramatically in the group of AGRE fathers who are 30–39 years inclusive, which is 54.7% of the distribution compared with the 41.9 % that is expected. We interpret this shifted age distribution to provide support for the recently reported finding by Reichenberg and co-workers that autism risk is associated with advancing paternal age. Labels: CM Lajonchere, J Furr, JL Yoon, RM Cantor http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10333115&query_hl=10&itool=pubmed_docsum
"The issue is that the older man will have sperm that has undergone more divisions and therefore had more chances to have mutations. The COMPLEXITY of the myelination process makes it more vulnerable to mutations. I am not talking of one specific mutation. Many things could MANIFEST in the myelination or myelin breakdown process because it is so vulnerable - something going slightly wrong will impact it while it will not impact bone growth or the heart. A good example is ApoE4 - whatever else it may affect, it manifests in the reduced capacity of myelin repair and earlier onset of AD." George Bartzokis
The massive effort over the last 50 years by big Pharma and others to cover up and detract from the science showing the paternal age effect on many, many genetic disorders such as Alzheimer's, autism, schizophrenia, diabetes, MS, Crohn's, fibromyalgia, Duchennes's, hemophilia, mental retardation, prostate cancer, etc. etc. has been so successful that most people will argue that there is no male biological clock that affects offspring's risk genetic disorders from their deepest conditioning. The facts show that the very opposite is true and that sperm stem cell DNA is very prone to mutation with age and toxic exposures.
ReplyDeleteAnd why would that be in Big Pharma's best interest?
ReplyDeleteAnd how would you "cover up" something for 50 years?
These kinds of sweeping accusations help Big Pharma, because they can point to the people using these comments and claim anyone critical is a lunatic.
Gimme a break.
Sure, there are lots of things we don't know, I'm sure that includes impact of paternal age, but to say there is a big conspiracy because what you think is true has not been widely validated or accepted simply helps nail you to the cross.
Some of the studies on paternal age and genetic disorders are cited below. Why is this science unknown to the general public and to doctors who have been taught there is no male biological clock?
ReplyDeletehttp://clinpsyc.blogspot.com/search/label/paternal%20age
http://justnoticeabledifferences.blogspot.com/2007/03/fathers-age-and-serious-mental-illness.html
http://list.web.net/archives/mnchp-l/2004-April/000508.html
"New point mutations in humans are introduced through the male line," says
Dolores Malaspina, MD, professor of clinical psychiatry at Columbia
University and the New York State Psychiatric Institute. Furthermore, she
adds, the number of mutations in sperm increases as men age.
"This has been known since the 50s," said Malaspina. "What is intriguing is
why society chooses to ignore this." Society is starting to pay attention. With many couples now deferring
childbearing until they are older, the issue of paternal age and increased
risk for birth defects is gaining a higher profile. It is also possible, say
some experts, that if current trends of older fatherhood continue, it could
someday become a public health problem as well as a personal one."
http://www.schizophreniaforum.org/for/curr/Malaspina/default.asp
http://www.vhi.ie/news/n250607b.jsp
http://www.hindustantimes.com/StoryPage/StoryPage.aspx?id=cd0ffe5a-ad86-481b-ad17-fda4aa694e6c&&Headline=It%e2%80%99s+Waning+Men%2c+Hallelujah
http://archpedi.ama-assn.org/cgi/content/abstract/161/4/326
http://www.pnas.org/cgi/reprint/94/16/8380
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17053003&query_hl=1&itool=pubmed_docsum
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=1590260&query_hl=6&itool=pubmed_docsum
Mol Psychiatry. 2007 May;12(5):419-421.Paternal age and autism are associated in a family-based sample.Cantor RM, Yoon JL, Furr J, Lajonchere CM.
[1] 1Department of Human Genetics, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA, USA [2] 2Department of Pediatrics, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA, USA [3] 3AGRE Consortium, Los Angeles, CA, USA.
PMID: 17453057 [PubMed - as supplied by publisher]
The paternal age distribution of the AGRE fathers, whose first child is autistic differs significantly from that of the 'control' sample (P=0.005). A 2 goodness-of-fit test with 2 degrees of freedom was conducted using percents in the 'control' group age categories to calculate the expected values in the AGRE sample. The shift toward higher paternal ages in those with an affected first-born is seen most dramatically in the group of AGRE fathers who are 30–39 years inclusive, which is 54.7% of the distribution compared with the 41.9 % that is expected. We interpret this shifted age distribution to provide support for the recently reported finding by Reichenberg and co-workers that autism risk is associated with advancing paternal age.
Labels: CM Lajonchere, J Furr, JL Yoon, RM Cantor
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10333115&query_hl=10&itool=pubmed_docsum
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17142012&query_hl=17&itool=pubmed_docsum
http://www.bmj.com/cgi/content/full/329/7474/1070
http://seattletimes.nwsource.com/html/health/2003303295_carnalknowledge15.html
http://www.intelihealth.com/IH/ihtIH/WS/35320/63153/491833.html?d=dmtHMSContent
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10732803&query_hl=6&itool=pubmed_docsum
"The issue is that the older man will have sperm that has undergone more divisions and therefore had more chances to have mutations.
The COMPLEXITY of the myelination process makes it more vulnerable to mutations. I am not talking of one specific mutation. Many things could MANIFEST in the myelination or myelin breakdown process because it is so vulnerable - something going slightly wrong will impact it while it will not impact bone growth or the heart. A good example is ApoE4 - whatever else it may affect, it manifests in the reduced capacity of myelin repair and earlier onset of AD." George Bartzokis
http://press.psprings.co.uk/jech/october/851_ch45179.pdf
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=2910259&query_hl=21&itool=pubmed_DocSum
http://aje.oxfordjournals.org/cgi/content/abstract/161/9/816
http://uwnews.washington.edu/ni/article.asp?articleID=2521
http://humrep.oxfordjournals.org/cgi/reprint/13/9/2371.pdf
http://www.springerlink.com/content/p6h7k46626168702/
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=15475721&dopt=Abstract
http://how-old-is-too-old.blogspot.com/search/label/Leslie%20B.%20Raschka
http://aje.oxfordjournals.org/cgi/reprint/150/11/1208
http://www.llnl.gov/pao/news/news_releases/2006/NR-06-06-01.html
http://www.greenjournal.org/cgi/content/abstract/57/6/745
http://www.pnas.org/cgi/content/full/103/25/9601
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17433321&query_hl=2&itool=pubmed_docsum
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12410007&query_hl=42&itool=pubmed_docsum
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10230837&query_hl=14&itool=pubmed_DocSum
http://www.ncbi.nlm.nih.gov/sites/entrez?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=7211951
http://www.sciencedaily.com/releases/2002/10/021018080014.htm